Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

To a solution of (R)-tert-butyl 5-(((R)-1-(2-fluorophenyl)ethyl)(4-(methoxycarbonyl)benzyl)carbamoyl)-3,3-dimethyl-1,3-azasilolidine-1-carboxylate (85 mg, 0.16 mmol) in DCM (4 mL) was added HCl (4.0 M solution in dioxane, 1.5 mL, 6.0 mmol). The resulting reaction mixture was stirred at rt for 1 h and concentrated in vacuo to give the title compound as a HCl salt (74 mg, 99%, white solid). 1H NMR (DMSO-d6) δ 7.92-7.74 (m, 1H), 7.68 (d, J=8.1 Hz, 1H), 7.60-7.41 (m, 1H), 7.35-7.06 (m, 3H), 7.03 (d, J=8.4 Hz, 1H), 6.96-6.75 (m, 1H), 5.71-5.43 (m, 1H), 4.85-4.41 (m, 2H), 4.37-4.12 (m, 1H), 3.88-3.77 (m, 3H), 3.73-3.48 (m, 1H), 2.70-2.54 (m, 1H), 2.34-2.13 (m, 1H), 1.73-1.56 (m, 2.5H), 1.47 (d, J=7.0 Hz, 0.5H), 1.39-1.17 (m, 1H), 1.00-0.63 (m, 1H), 0.45-0.17 (m, 6H); MS(ESI+) m/z 429.8 (M+H)+.

Provenance & Evidence