反应详情

Sodium t-butoxide (4.86 g, 50.6 mmol) was added portionwise to a stirred mixture of (S)-2-hexanol (12 g, 117 mmol) and 1,2-dimethoxyethane (12 ml). The resultant mixture was heated to 50° C. under an atmosphere of nitrogen and then 2-fluoro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (3 g, 12.65 mmol) was added. The resultant mixture was maintained at 50° C. for 20 hours when LCMS indicated complete reaction. The mixture was cooled to room temperature and partitioned between ethyl acetate (100 ml) and water (100 ml). The organic phase was washed with water (100 ml) then saturated brine (50 ml), dried over anhydrous magnesium sulphate, filtered and evaporated. The residue was dissolved in dichloromethane and purified on an aminopropyl (NH2) cartridge (100 g) eluting with a 0-100% ethyl acetate in cyclohexane gradient over 40 mins. The appropriate fractions were combined and evaporated in vacuo to give the title compound as a white foam (1.665 g).

1. customreaction
2. custompartitioned between ethyl acetate (100 ml) and water (100 ml)
3. washThe organic phase was washed with water (100 ml)
4. dry with materialsaturated brine (50 ml), dried over anhydrous magnesium sulphate
5. filtrationfiltered
6. customevaporated
7. dissolutionThe residue was dissolved in dichloromethane
8. custompurified on an aminopropyl (NH2) cartridge (100 g)
9. washeluting with a 0-100% ethyl acetate in cyclohexane gradient over 40 mins
10. customevaporated in vacuo