1-Bromo-4-chlorobutane → 9-(4-Chlorobutyl)-2-(cyclobutyloxy)-8-(methyloxy)-9H-purin-6-amine

HRID 527815Notes

Reaction equation

HRID 527815 reaction equation
FC(F)(F)C(O)=O.[CH:8]1([O:12][C:13]2[NH:14][C:15]([NH2:24])=[C:16]3[C:20]([N:21]=2)=[N:19][C:18]([O:22][CH3:23])=[N:17]3)[CH2:11][CH2:10][CH2:9]1.Br[CH2:26][CH2:27][CH2:28][CH2:29][Cl:30]>>[Cl:30][CH2:29][CH2:28][CH2:27][CH2:26][N:19]1[C:18]([O:22][CH3:23])=[N:17][C:16]2[C:20]1=[N:21][C:13]([O:12][CH:8]1[CH2:9][CH2:10][CH2:11]1)=[N:14][C:15]=2[NH2:24]

Participants

3

Reactant 2

HCID 813641-Bromo-4-chlorobutaneHCID 178494005HCID 178494005, compound

Product 1

HCID 592526079-(4-Chlorobutyl)-2-(cyclobutyloxy)-8-(methyloxy)-9H-purin-6-amine

Procedure

Prepared similarly to Intermediate 44 from 2-(cyclobutyloxy)-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and 1-bromo-4-chlorobutane.

Sources & evidence

ORD record
ord-234ce1b58ec04680afc75ca0efb46219
Source dataset
uspto-grants-2016_05
Patent number
US09346806B2

Reaction notes

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