1-Bromo-4-chlorobutane → 9-(4-Chlorobutyl)-2-(cyclopentyloxy)-8-(methyloxy)-9H-purin-6-amine

HRID 527817Notes

Reaction equation

HRID 527817 reaction equation
FC(F)(F)C(O)=O.[CH:8]1([O:13][C:14]2[NH:15][C:16]([NH2:25])=[C:17]3[C:21]([N:22]=2)=[N:20][C:19]([O:23][CH3:24])=[N:18]3)[CH2:12][CH2:11][CH2:10][CH2:9]1.Br[CH2:27][CH2:28][CH2:29][CH2:30][Cl:31]>>[Cl:31][CH2:30][CH2:29][CH2:28][CH2:27][N:20]1[C:19]([O:23][CH3:24])=[N:18][C:17]2[C:21]1=[N:22][C:14]([O:13][CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12]1)=[N:15][C:16]=2[NH2:25]

Participants

3

Reactant 2

HCID 813641-Bromo-4-chlorobutaneHCID 178494007HCID 178494007, compound

Product 1

HCID 592525909-(4-Chlorobutyl)-2-(cyclopentyloxy)-8-(methyloxy)-9H-purin-6-amine

Procedure

Prepared similarly to Intermediate 44 from 2-(cyclopentyloxy)-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and 1-bromo-4-chlorobutane.

Sources & evidence

ORD record
ord-6d8f260528e84f75a63f6519a4b41264
Source dataset
uspto-grants-2016_05
Patent number
US09346806B2

Reaction notes

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