1-Bromo-4-chlorobutane → HCID 59252588, compound

HRID 527828Notes

Reaction equation

HRID 527828 reaction equation
FC(F)(F)C(O)=O.[CH3:8][C@H:9]([NH:13][C:14]1[NH:22][C:21]2[C:17]([N:18]=[C:19]([O:23][CH3:24])[N:20]=2)=[C:16]([NH2:25])[N:15]=1)[CH2:10][CH2:11][CH3:12].Br[CH2:27][CH2:28][CH2:29][CH2:30][Cl:31]>>[Cl:31][CH2:30][CH2:29][CH2:28][CH2:27][N:20]1[C:19]([O:23][CH3:24])=[N:18][C:17]2[C:21]1=[N:22][C:14]([NH:13][C@@H:9]([CH3:8])[CH2:10][CH2:11][CH3:12])=[N:15][C:16]=2[NH2:25]

Participants

3

Reactant 2

HCID 813641-Bromo-4-chlorobutaneHCID 178448280HCID 178448280, compound

Product 1

HCID 59252588HCID 59252588, compound

Procedure

Prepared similarly to Intermediate 44 from N2-[(1S)-1-methylbutyl]-8-(methyloxy)-3H-purine-2,6-diamine trifluoroacetate and 1-bromo-4-chlorobutane.

Sources & evidence

ORD record
ord-e8accf2b79cf482c9c86fff54d9c20ab
Source dataset
uspto-grants-2016_05
Patent number
US09346806B2

Reaction notes

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