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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 527878Generated: October 25, 2026

8-Boc-3,8-diaza-bicyclo(3.2.1)octane → 3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/527878

Reaction equation

Participants

RoleNameHCIDCharge
Reactant8-Boc-3,8-diaza-bicyclo(3.2.1)octaneHCID 15740908—
Reactanttert-Butyl 4,7-diazaspiro(2.5)octane-4-carboxylateHCID 51358567—
Reactant7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diazaspiro[2.5]octane-4-carboxylic acid tert-butyl esterHCID 57477280—
Product3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl esterHCID 57477265—

Reaction Steps

Prepared in a way similar to Intermediate 1, using 3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester, instead of 4,7-diaza-spiro[2.5]octane-4-carboxylic acid tert-butyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09346809B2
Source datasetuspto-grants-2016_05
ORD IDord-480b82ed36624265aaf7d516d070a956
Source noteuspto-grants-2016_05