(1S,4S)-tert-butyl 2,5-diazabicyclo(2.2.1)heptane-2-carboxylate → HCID 66888930, compound

HRID 527879Notes

Reaction equation

HRID 527879 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:15][CH2:14][N:13]([C:16]2[C:17]3[CH:24]=[CH:23][NH:22][C:18]=3[N:19]=[CH:20][N:21]=2)[CH2:12][C:9]21[CH2:11]C2)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OC(N1CC2CC1CN2)=O)(C)(C)C.C(OC(N1CCNCC21CC2)=O)(C)(C)C>>[C:1]([O:5][C:6]([N:8]1[CH2:15][CH:14]2[CH2:11][CH:9]1[CH2:12][N:13]2[C:16]1[C:17]2[CH:24]=[CH:23][NH:22][C:18]=2[N:19]=[CH:20][N:21]=1)=[O:7])([CH3:2])([CH3:4])[CH3:3]

Participants

4

Reactant 3

HCID 2760898(1S,4S)-tert-butyl 2,5-diazabicyclo(2.2.1)heptane-2-carboxylateHCID 51358567tert-Butyl 4,7-diazaspiro(2.5)octane-4-carboxylateHCID 574772807-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diazaspiro[2.5]octane-4-carboxylic acid tert-butyl ester

Product 1

HCID 66888930HCID 66888930, compound

Procedure

Prepared in a way similar to Intermediate 1, using 2,5-diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester, instead of 4,7-diaza-spiro[2.5]octane-4-carboxylic acid tert-butyl ester.

Sources & evidence

ORD record
ord-4c392866acbf456d87b17af73015f28a
Source dataset
uspto-grants-2016_05
Patent number
US09346809B2

Reaction notes

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