HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 49869895, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-(Trifluoromethyl)benzoic acid | HCID 9966 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 66888703 | HCID 66888703 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 49869895 | HCID 49869895 | — |
Reaction Steps
4-(3,8-Diaza-bicyclo[3.2.1]oct-3-yl)-7H-pyrrolo[2,3-d]pyrimidine (intermediate 4) (0.05 mmol) was dissolved in dry DMF (0.3 mL). Triethylamine (0.18 mmol) and HATU (0.09 mmol) was added followed by 4-trifluoromethylbenzoic acid (0.07 mmol). The reaction mixture was left at it for 16 hours. The pure compounds were obtained by standard preparative HPLC purification of the reaction mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09346809B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-8fb9227c82dc4f9590fa32d287c71319 |
| Source note | uspto-grants-2016_05 |