HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 7-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diaza-spiro[2.5]octane-4-sulfonic acid (2-cyano-ethyl)-methyl-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Cyanoethyl(methyl)sulfamoyl chloride | HCID 16769783 | — |
| Reactant | 2,2-Dimethyl-3-oxo-3-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-propionitrile | HCID 66888322 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diaza-spiro[2.5]octane-4-sulfonic acid (2-cyano-ethyl)-methyl-amide | HCID 66899474 | — |
Reaction Steps
Intermediate 2 (0.05 mmol) was dissolved in THF (1.0 mL). Triethylamine (0.12 mmol) and 2-cyanoethyl(methyl)sulfamoyl chloride (0.06 mmol) was added. The reaction mixture was left at it for 16 hours. The pure compounds were obtained by standard preparative HPLC purification of the reaction mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09346809B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-bc475b75b06d44b1b495017d51fc0841 |
| Source note | uspto-grants-2016_05 |