HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-[4-(2-Methyl-propane-2-sulfinyl)-4,7-diaza-spiro[2.5]oct-7-yl]-7H-pyrrolo[2,3-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Methylpropane-2-sulfinyl chloride | HCID 4686861 | — |
| Reactant | 2,2-Dimethyl-3-oxo-3-[3-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-propionitrile | HCID 66888322 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[4-(2-Methyl-propane-2-sulfinyl)-4,7-diaza-spiro[2.5]oct-7-yl]-7H-pyrrolo[2,3-d]pyrimidine | HCID 66887402 | — |
Reaction Steps
Intermediate 2 (0.05 mmol) was dissolved in THF (1.0 mL). Triethylamine (0.12 mmol) and 2-methylpropane-2-sulfinyl chloride (0.06 mmol) was added. The reaction mixture was left at rt for 16 hours. The pure compounds were obtained by standard preparative HPLC purification of the reaction mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09346809B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-357279ac72d94362a91dc6eb4310b949 |
| Source note | uspto-grants-2016_05 |