Cyclopentanone → HCID 86692133, compound

Participants

Reaction Steps

To a solution of (R)-tert-butyl 3-aminopyrrolidine-1-carboxylate (1.0 g, 5.3 mmol) and cyclopentanone (451 mg, 5.3 mmol) in THF (20 mL) was slowly added NaBH(OAc)3 (1.13 g, 5.3 mmol) and then stirred at the ambient temperature for overnight. The reaction was quenched with H2O (20 mL) and extracted with dichloromethane (3×20 mL). The combined extracts were washed with brine (3×5 mL), dried over anhydrous Na2SO4, filtered and concentrated to give the title compound. MS (m/z): 255 (M+H)+.

Provenance & Evidence