Propanal → HCID 68027530, compound

Participants

Reaction Steps

A mixture of (R)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine hydrochloride (50 mg, 0.24 mmol), propionaldehyde (15 mg, 0.26 mmol) and NaBH(OAC)3 (61 mg, 1.2 mmol) in THF (5 mL) was stirred at the ambient temperature for minutes. It was then quenched with water (2 mL) and extracted with EtOAc (3×10 mL). The combined extracts were washed with brine (3×5 mL), dried over anhydrous Na2SO4, filtered, and concentrated to give the title compound. MS (m/z): 246 (M+H)+.

Provenance & Evidence