HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 6-chloro-N,N-dimethylpyridine-3-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chloro-5-pyridinesulfonyl chloride | HCID 2792792 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 6-chloro-N,N-dimethylpyridine-3-sulfonamide | HCID 4729855 | 95% |
Reaction Steps
A solution of 6-chloropyridine-3-sulfonyl chloride (1 mmol), dimethylamine (2 mmol) and Et3N (2 mmol) in THF (2 mL) was stirred at room temperature for 30 minutes. The mixture was diluted with EtOAc, washed with brine, dried, filtered, and concentrated to give the title compound in 95% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09346810B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-995e599984434e7b8d9b88497122cb76 |
| Source note | uspto-grants-2016_05 |