反应详情

温度

80 °C

A solution of 4-ethoxy-aniline (commercial; 3.2 mL) in EtOH/water (9:1; 150 mL) was reacted with (2R)-2-[2-[[(tert-butyl)dimethylsilyl]oxy]ethyl]-oxirane (prepared according to WO 2007/144423) and further heated at 80° C. overnight. The solvents were removed under reduced pressure and the residue was purified by CC (EA/Hept 1:1), affording a brown oil (5.22 g; 62% yield).

1. customThe solvents were removed under reduced pressure
2. customthe residue was purified by CC (EA/Hept 1:1)
3. customaffording a brown oil (5.22 g; 62% yield)