Chloroacetyl chloride → 2-Chloro-N-(4-fluorophenyl)-N-(1-methylethyl)acetamide

Participants

Reaction Steps

357.5 parts (3.2 mol) of chloroacetyl chloride are added dropwise over the course of 2 hours at from 10° to 20° C. to 920 parts of 4-fluoro-N-isopropylaniline solution (~3 mol of 4-fluoro-N-isopropylaniline) from Example 1. Stirring is subsequently carried out at 20° C. for one hour and then the majority of the hydrogen chloride formed is removed as a gas by heating to about 90° C.

Provenance & Evidence