3-((Tert-butyldimethylsilyl)oxy)propanal → HCID 90149715, compound

HRID 527980Notes

Reaction equation

HRID 527980 reaction equation
[F:1][C:2]1[C:11]2[CH:12]([NH:14][CH2:15][CH2:16][CH2:17][C@H:18]3[O:22][C:21](=[O:23])[N:20]([C:24]4[CH:25]=[CH:26][C:27]5[S:32][CH2:31][C:30](=[O:33])[NH:29][C:28]=5[CH:34]=4)[CH2:19]3)[CH2:13][N:9]3[C:10]=2[C:5]([CH:6]=[CH:7][C:8]3=[O:35])=[CH:4][CH:3]=1.[Si:36]([O:43][CH2:44][CH2:45][CH:46]=O)([C:39]([CH3:42])([CH3:41])[CH3:40])([CH3:38])[CH3:37]>>[C:39]([Si:36]([CH3:38])([CH3:37])[O:43][CH2:44][CH2:45][CH2:46][N:14]([CH2:15][CH2:16][CH2:17][C@H:18]1[O:22][C:21](=[O:23])[N:20]([C:24]2[CH:25]=[CH:26][C:27]3[S:32][CH2:31][C:30](=[O:33])[NH:29][C:28]=3[CH:34]=2)[CH2:19]1)[CH:12]1[C:11]2=[C:10]3[C:5](=[CH:4][CH:3]=[C:2]2[F:1])[CH:6]=[CH:7][C:8](=[O:35])[N:9]3[CH2:13]1)([CH3:42])([CH3:41])[CH3:40]

Participants

3

Reactant 2

HCID 36623923-((Tert-butyldimethylsilyl)oxy)propanalHCID 67351668HCID 67351668, compound

Product 1

HCID 90149715HCID 90149715, compoundYield 46%

Procedure

Starting from the compound of Example 13 and 3-(tert-butyldimethylsilyloxy)-propionaldehyde and using procedure E, the title compound was obtained as a yellow foam (62 mg; 46% yield).

Sources & evidence

ORD record
ord-ec87348f620d448b9d7e68f7b88bd0bd
Source dataset
uspto-grants-2016_05
Patent number
US09346804B2

Reaction notes

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