Dimethylcarbamoyl Chloride → HCID 90418434, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Example 75B (4.25 g, 10.33 mmol) and diisopropylethylamine (5.41 ml, 31.0 mmol) in 120 mL dichloromethane was added dimethylcarbamic chloride (1.333 g, 12.40 mmol). The mixture was stirred at 15° C. for 5 hours. The reaction was concentrated in vacuo, and the crude material was purified via flash chromatography: Analogix Intelliflash™ 280, 80 g silica column, 1:1 hexane/ethyl acetate to give the title compound. LC-MS (ESI+) m/z 446.0 (M+H)+.

Provenance & Evidence