Lithium hydroxide, monohydrate → HCID 86271573, compound

Participants

Reaction Steps

To a solution of Example 86A (266 mg, 0.556 mmol) in 4 mL of tetrahydrofuran/water (3:1) was added lithium hydroxide mono hydrate (46.7 mg, 1.112 mmol). The reaction was stirred at room temperature overnight. The volatiles were then removed, and the residue dissolved in 5 mL water and the pH was adjusted to pH ˜6-7 with 1 M hydrochloric acid. The solid was collected by filtration and dried under high vacuum overnight to give the title compound as a hydrochloride salt. 1H NMR (400 MHz, DMSO-d6) δ 12.26 (s, 1H) 8.81 (s, 1H) 7.13-7.52 (m, 3H) 6.62 (s, 1H) 6.32 (s, 1H) 3.83 (s, 3H) 3.32 (d, J=21.06 Hz, 2H) 2.67-2.86 (m, 2H) 2.56 (s, 1H) 2.41 (s, 1H) 2.10-2.27 (m, 1H) 1.83-2.08 (m, 3H) 1.24-1.76 (m, 6H). MS (ESI+) m/z 451.1 (M+H)+.

Provenance & Evidence