反应详情

A stirred solution of 4,6-dichloropyrimidin-5-amine (10 g, 60.9 mmol) and cycloproplyamine (10.44 g, 182.93 mmol, 12.7 mL) in absolute ethanol (100 mL) wee heated at 125° C. in a sealed tube for 4 days. The reaction mixture was then concentrated under reduced pressure to give a yellow solid which was triturated with cold water (200 mL). The resulting slurry was stirred for one hour at room temperature and then filtered. The isolated solid was washed with water (2×25 mL) and dried under reduced pressure to give 11.32 g of the title compound as a pale yellow solid, which was used without any further purification.

1. concentrationThe reaction mixture was then concentrated under reduced pressure
2. customto give a yellow solid which
3. customwas triturated with cold water (200 mL)
4. filtrationfiltered
5. washThe isolated solid was washed with water (2×25 mL)
6. customdried under reduced pressure