6-chloro-N4-cyclopropylpyrimidine-4,5-diamine → HCID 86711710, compound

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Reaction Steps

4-chloro-8-cyclopropyl-6-methoxypteridin-7(8H)-one was prepared in the same manner as 4-chloro-8-methyl-6-methoxypteridin-7(8H)-one. The reaction of 6-Chloro-N4-cyclopropyl-pyrimidine-4,5-diamine (3.00 g, 16.2 mmol), methyl 2,2,2-trimethocyacetate (3.73 g, 22.7 mmol), 1-camphorsulfonic acid (0.754 g, 3.25 mmol) in acetonitrile (30 mL) at 80° C. for 16 hours gave 3.045 g of 4-chloro-8-cyclopropyl-6-methoxypteridin-7(8H)-one as a tan colored solid. 1H NMR (400 MHz, DMSO-d6): δ 8.75 (s, 1H), 4.01 (s, 3H), 2.95 (m, 1H), 1.16 (m, 2H), 0.86 (m, 2H). MS (EI) C10H9ClN4O2: 253 (MH+).

Provenance & Evidence