Diisopropylethylamine → 1-(8-Bromo-9-methyl-9H-purin-6-yl)-4-phenylpiperidine-4-carbonitrile

Participants

Reaction Conditions

Reaction Steps

8-bromo-6-chloro-9-methyl-9H-purine (200 mg, 0.80 mmol) was dissolved in DMF (4 mL). To this solution was added diisopropylethylamine (0.21 mL, 1.21 mmol). To this stirred mixture was added 4-cyano-4-phenylpiperidine hydrochloride (165 mg, 0.88 mmol) dissolved in a small amount of DMF. The resulting mixture was heated to 70° C. and stirred for 30 minutes. The solvent was removed in vacuo and the crude material was used without purification.

Provenance & Evidence