HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Isopropylaniline → 5-fluoro-N4-(3-hydroxyphenyl)-N2-(4-isopropylphenyl)-2,4-pyrimidinediamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Isopropylaniline | HCID 7464 | — |
| Reactant | 2-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamine | HCID 22060451 | — |
| Product | 5-fluoro-N4-(3-hydroxyphenyl)-N2-(4-isopropylphenyl)-2,4-pyrimidinediamine | HCID 22060781 | — |
Reaction Steps
In like manner to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine, the reaction of 2-chloro-5-fluoro-N4-(3-hydroxyphenyl)-4-pyrimidineamine with 4-isopropylaniline gave 5-fluoro-N4-(3-hydroxyphenyl)-N2-(4-isopropylphenyl)-2,4-pyrimidinediamine. LCMS: ret. time: 23.08 min.; purity: 99%; MS (m/e): 439 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09346765B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-78009d2815fd4e53baf333eebb3d570b |
| Source note | uspto-grants-2016_05 |