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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 528297Generated: October 30, 2026

3-Aminophenol → 5-fluoro-N2-(3-hydroxyphenyl)-N4-[di-(4-chlorophenyl)methyl]-2,4-pyrimidinediamine

https://huagongshe.com/reaction/528297

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-AminophenolHCID 11568—
ReactantN-(2-chloro-5-fluoropyrimidinyl)-1,1-di(4-chlorophenyl)methylamineHCID 86591126—
Product5-fluoro-N2-(3-hydroxyphenyl)-N4-[di-(4-chlorophenyl)methyl]-2,4-pyrimidinediamineHCID 22060291—

Reaction Steps

In like manner to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-4-pyrimidinediamine, 3-aminophenol and N-(2-chloro-5-fluoropyrimidinyl)-1,1-di(4-chlorophenyl)methylamine produced 5-fluoro-N2-(3-hydroxyphenyl)-N4-[di-(4-chlorophenyl)methyl]-2,4-pyrimidinediamine. LCMS: ret. time: 25.59 min.; purity: 91%; MS (m/e): 421 (MH+—Cl).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09346765B2
Source datasetuspto-grants-2016_05
ORD IDord-a6c017989276401bbb95a97d02a669e7
Source noteuspto-grants-2016_05