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HRID528306

反应详情

EQUATION

反应方程式

HRID 528306 的结构方程式

REACTANTS

反应物

2
结构：Nc1cccc(-c2cnco2)c1
HCID2739289

3-(1,3-oxazol-5-yl)aniline

C9H8N2O

结构：Fc1cnc(Cl)nc1Nc1ccc2c(c1)OCCO2
HCID22060362

未命名化合物

PRODUCTS

生成物

1
结构：Fc1cnc(Nc2cccc(-c3cnco3)c2)nc1Nc1ccc2c(c1)OCCO2
HCID11668581

未命名化合物

PROCEDURE

实验过程

In like manner to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine, the reaction of 2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine with 3-(1,3-oxazol-5-yl)aniline gave N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-[3-(1,3-oxazol-5-yl)phenyl]-2,4-pyrimidinediamine. LCMS: ret. time: 20.25 min.; purity: 81%, MS (m/e): 406 (MH+).

WORKUP

后处理

  1. customIn like manner to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine