反应详情

In a 30ml round-bottom flask, 0.47 g (1.48 m mole) of 2-(6-hydroxy-2-naphthyl)-5-butylbenzooxazole, 0.43 g (1.79 m mole) of octyl iodide, 0.12 g (1.82 m mole) of potassium hydroxide and 5 ml of butanol were placed, followed by refluxing for 310 minutes. The reaction mixture was poured into water, extracted from ethyl acetate to obtain an organic layer. The organic layer was washed with water dried with mirabilite and dried under reduced pressure to obtain a resultant. The resultant was recrystallized from ethylacetate to obtain a crystal. The crystal was filtered, purified by silica gel column chromatography (eluent: toluene) and recrystallized from acetone to obtain 0.36 g of 2-(6-octyloxy-2-naphthyl)-5-butylbenzooxazole (Yield: 56.6%). ##STR190##

1. temperatureby refluxing for 310 minutes
2. extractionextracted from ethyl acetate
3. customto obtain an organic layer
4. washThe organic layer was washed with water
5. dry with materialdried with mirabilite
6. customdried under reduced pressure
7. customto obtain a resultant
8. customThe resultant was recrystallized from ethylacetate
9. customto obtain a crystal
10. filtrationThe crystal was filtered
11. custompurified by silica gel column chromatography (eluent: toluene)
12. customrecrystallized from acetone