反应详情

To a solution of the 1-(4-bromo-indazol-1-yl)-ethanone A (3.09 g, 12.9 mmol) in MeOH (50 mL) was added 6N aqueous HCl (30 mL) and the mixture was stirred at room temperature for 7 h. The MeOH was evaporated and the mixture partitioned between EtOAc (2×50 mL) and water (50 mL). The combined organic layers were washed with brine (50 mL), separated and dried (MgSO4). The solvent was removed by evaporation under reduced pressure to give 4-bromo-1H-indazole B (2.36 g, 93%).

1. customThe MeOH was evaporated
2. customthe mixture partitioned between EtOAc (2×50 mL) and water (50 mL)
3. washThe combined organic layers were washed with brine (50 mL)
4. customseparated
5. dry with materialdried (MgSO4)
6. customThe solvent was removed by evaporation under reduced pressure