Hydrochloric Acid → HCID 118057354, compound

Participants

Reaction Steps

To a reaction vessel, 15 g (0.039 mol) compound XII and 300 ml 10% solution of hydrogen chloride in ethyl acetate were added, the reaction mixture was kept at room temperature for 30 min until the reaction was complete, concentrated to dry under reduced pressure, recrystallized with the mixed solution of ethanol and ethyl acetate, and 10.5 g compound II-2 was obtained, with yield of 84.3%. 1H NMR (D2O): δ 1.38-1.49 (m, 2H), 1.59-1.61 (m, 3H), 1.98 (d, 2H, J=13.5 Hz), 2.91-2.98 (m, 2H), 3.42 (d, 2H, J=12.8 Hz), 3.49 (t, 2H, J=7.0 Hz), 4.13 (s, 2H), 5.97 (s, 2H), 6.72 (s, 1H), 6.76 (s, 1H); MS (ESI): m/z 289 [M−Cl]+.

Provenance & Evidence