Hydrochloric Acid → HCID 118207084, compound

Participants

Reaction Steps

To a reaction vessel, 5 g (0.012 mol) compound XIII, 30 ml ethanol and 100 ml 10% solution of hydrogen chloride in ethyl acetate were added, the reaction was kept at room temperature for 1-1.5 h, filtered, the filter cake was washed with ethyl acetate, dried, and 3.4 g compound II-3 was obtained, with yield of 81%. 1H NMR (D2O): δ 1.24 (d, 3H, J=7.0 Hz), 1.44-1.58 (m, 5H), 1.98 (m, 2H), 2.96 (m, 2H), 3.21-3.25 (m, 1H), 3.44 (d, 2H, J=12.4 Hz), 3.64-3.72 (m, 1H), 4.34 (q, 1H, J=6.6 Hz), 5.94 (s, 2H), 6.72 (s, 1H), 6.79 (s, 1H); MS (ESI): m/z 303 [M+H]+.

Provenance & Evidence