Hydrochloric Acid → HCID 118057419, compound

Participants

Reaction Steps

To a reaction vessel, 2 g (0.0048 mol) compound XIV, 10 ml ethanol and 50 ml 10% solution of hydrogen chloride in ethyl acetate were added, the reaction was kept at room temperature for 1-1.5 h, filtrated, the filter cake was washed with ethyl acetate, dried, and 1.2 g compound II-4 was obtained, with yield of 71%. 1H NMR (D2O): δ 1.27 (s, 6H), 1.45 (m, 2H), 1.56 (q, 2H, J=6.9 Hz), 1.69 (br s, 1H), 2.00 (d, 2H, J=13.9 Hz), 3.00 (t, 2H, J=12.6 Hz), 3.37 (t, 2H, J=7.6 Hz), 3.45 (d, 2H, J=12.3 Hz), 5.96 (s, 2H), 6.79 (s, 1H), 6.86 (s, 1H); MS (ESI): m/z 317 [M-Cl]+.

Provenance & Evidence