Picolyl chloride hydrochloride → 6-[2-[1-(2-Pyridylmethyl)-4-piperidyl]ethyl]-[1,3]dioxolo[4,5-f]isoindole-5,7-dione

Participants

Reaction Steps

Compound I-36 was prepared according to the method in example 3, using 6-[2-(4-piperidyl)ethyl]-[1,3]dioxolo[4,5-f]isoindole-5,7-dione hydrochloride (compound II-1) and 2-chloromethylpyridine hydrochloride as the raw materials: 1H NMR (DMSO-d6): δ 1.12-1.19 (m, 3H), 1.48 (q, 2H, J=6.1 Hz), 1.67 (d, 2H, J=9.4 Hz), 1.94 (t, 2H, J=10.3 Hz), 2.76 (d, 2H, J=11.2 Hz), 3.54 (m, 4H), 6.27 (s, 2H), 7.24 (dd, 1H, J=6.8, 5.4 Hz), 7.38 (s, 2H), 7.42 (d, 1H, J=7.8 Hz), 7.74 (td, 1H, J=7.7, 1.4 Hz), 8.64 (d, 1H, J=4.2 Hz): m/z 394 [M+H]+.

Provenance & Evidence