Acetic Acid → HCID 89761947, compound

Participants

Reaction Conditions

Reaction Steps

A vial was charged with INTERMEDIATE T (0.250 g, 0.397 mmol), iron (0.222 g, 3.97 mmol), THF (0.25 mL), and acetic acid (0.25 mL). The vial was sealed and stirred at 70° C. for one hour. The mixture was diluted with DCM and MeOH, then filtered through a pad of Celite® (diatomaceous earth) and concentrated. The material was purified via silica gel chromatography (40 g, gradient elution 0 to 50% EtOAc:Heptane) to afford 3-amino-4-((2-chloro-4-(trifluoromethyl)phenyl)amino)-N-(2,4-dimethoxybenzyl)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (INTERMEDIATE U) as an off-white solid. m/z (ESI) 621.8 (M+Na)+.

Provenance & Evidence