HRID528524

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID578640

N-[(4-methoxyphenyl)methyl]-1,3-thiazol-2-amine

C11H12N2OS

结构：O=S(=O)(Cl)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1Cl

HCID89761722

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CN(c2nccs2)S(=O)(=O)c2ccc3c(c2)OCCN3c2ccc(C(F)(F)F)cc2Cl)cc1

HCID89761797

未命名化合物

PROCEDURE

实验过程

4-(2-chloro-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide (INTERMEDIATE X) was prepared in the same manner as INTERMEDIATE D, STEP 3, except employing INTERMEDIATE E and INTERMEDIATE W (N-(4-methoxybenzyl)thiazol-2-amine) m/z (ESI) 595.8 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7a04a9f9cab54a2e966ebf8f48210abf
来源数据集: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09346798B2
来源说明: uspto-grants-2016_05

反应 SMILES

[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][O:15][C:14]2[CH:18]=[C:19]([S:22](Cl)(=[O:24])=[O:23])[CH:20]=[CH:21][C:13]1=2.[CH3:26][O:27][C:28]1[CH:40]=[CH:39][C:31]([CH2:32][NH:33][C:34]2[S:35][CH:36]=[CH:37][N:38]=2)=[CH:30][CH:29]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][O:15][C:14]2[CH:18]=[C:19]([S:22]([N:33]([CH2:32][C:31]3[CH:39]=[CH:40][C:28]([O:27][CH3:26])=[CH:29][CH:30]=3)[C:34]3[S:35][CH:36]=[CH:37][N:38]=3)(=[O:24])=[O:23])[CH:20]=[CH:21][C:13]1=2