4-Aminopyrimidine → N-(4-methoxybenzyl)pyrimidin-4-amine

HRID 528569Notes

Reaction equation

HRID 528569 reaction equation
CO[C:3]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:4]=1[CH2:5][NH:6][C:7]1S[N:10]=[CH:9][N:8]=1.S1C(N)=NC=N1.N1C=[CH:28][C:27](N)=NC=1>>[CH3:17][O:16][C:14]1[CH:13]=[CH:12][C:4]([CH2:5][NH:6][C:7]2[CH:28]=[CH:27][N:10]=[CH:9][N:8]=2)=[CH:3][CH:15]=1

Participants

4

Reactant 3

HCID 689584-AminopyrimidineHCID 2902745-Amino-1,2,4-thiadiazoleHCID 57732216N-(2,4-dimethoxybenzyl)-1,2,4-thiadiazol-5-amine

Product 1

HCID 13230138N-(4-methoxybenzyl)pyrimidin-4-amine

Procedure

N-(4-methoxybenzyl)pyrimidin-4-amine (INTERMEDIATE AC) was prepared in a manner analogous to INTERMEDIATE A wherein 1,2,4-thiadiazol-5-amine was replaced with pyrimidin-4-amine

Sources & evidence

ORD record
ord-1f5d4fd2739840babae1146b4a91172e
Source dataset
uspto-grants-2016_05
Patent number
US09346798B2

Reaction notes

Loading…