Chloroacetone → 4-Amino-N-(4-methoxybenzyl)-3-(2-oxopropoxy)-1N-(thiazol-2-yl)benzenesulfonamide

HRID 528576Notes

Reaction equation

HRID 528576 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[C:12]2[S:16]N=[CH:14][N:13]=2)(=[O:10])=[O:9])=[CH:4][C:3]=1[O:26][CH2:27][C:28](=[O:35])[C:29]1C=CC=CC=1.Cl[CH2:37]C(=O)C>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([O:24][CH3:25])=[CH:22][CH:23]=2)[C:12]2[S:16][CH:37]=[CH:14][N:13]=2)(=[O:10])=[O:9])=[CH:4][C:3]=1[O:26][CH2:27][C:28](=[O:35])[CH3:29]

Participants

3

Reactant 2

HCID 6571ChloroacetoneHCID 897613554-amino-N-(4-methoxybenzyl)-3-(2-oxo-2-phenylethoxy)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

Product 1

HCID 897611614-Amino-N-(4-methoxybenzyl)-3-(2-oxopropoxy)-1N-(thiazol-2-yl)benzenesulfonamide

Procedure

4-Amino-N-(4-methoxybenzyl)-3-(2-oxopropoxy)-1N-(thiazol-2-yl)benzenesulfonamide was prepared from INTERMEDIATE AD in the same manner as described for INTERMEDIATE Q, using 1-chloropropan-2-one instead of 2-bromo-1-phenylethanone.

Sources & evidence

ORD record
ord-eca6ebe4240544eda4ae48bce5973d57
Source dataset
uspto-grants-2016_05
Patent number
US09346798B2

Reaction notes

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