4-Amino-N-(4-methoxybenzyl)-3-(2-oxopropoxy)-1N-(thiazol-2-yl)benzenesulfonamide → HCID 89761641, compound

HRID 528577Notes

Reaction equation

HRID 528577 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[C:12]2[S:13][CH:14]=[CH:15][N:16]=2)(=[O:10])=[O:9])=[CH:4][C:3]=1[O:26][CH2:27][C:28](=O)[CH3:29].C(C1C=C(C(F)(F)F)C=CC=1N1C[C@@H](C)OC2C=C(S(NC3SC=CN=3)(=O)=O)C=CC1=2)#N>>[CH3:25][O:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][N:11]([C:12]2[S:13][CH:14]=[CH:15][N:16]=2)[S:8]([C:5]2[CH:6]=[CH:7][C:2]3[NH:1][CH:28]([CH3:29])[CH2:27][O:26][C:3]=3[CH:4]=2)(=[O:10])=[O:9])=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 897611614-Amino-N-(4-methoxybenzyl)-3-(2-oxopropoxy)-1N-(thiazol-2-yl)benzenesulfonamideHCID 89761476(R)-4-(2-Cyano-4-(Trifluoromethyl)Phenyl)-2-Methyl-N-(Thiazol-2-Yl)-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine-7-Sulfonamide

Product 1

HCID 89761641HCID 89761641, compound

Procedure

N-(4-methoxybenzyl)-3-methyl-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide was prepared from 4-amino-N-(4-methoxybenzyl)-3-(2-oxopropoxy)-N-(thiazol-2-yl)benzenesulfonamide in a similar manner to that described for the synthesis of INTERMEDIATE R.

Sources & evidence

ORD record
ord-e949ad4417904ce9876e9645f21e3fd6
Source dataset
uspto-grants-2016_05
Patent number
US09346798B2

Reaction notes

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