HRID528580

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1268075

3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine

C6H2ClF4N

HCID89761919

未命名化合物

PRODUCTS

产物

HCID89761961

未命名化合物

PROCEDURE

实验过程

4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxybenzyl)-N-(pyrimidin-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide was synthesized from N-(4-methoxybenzyl)-N-(pyrimidin-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide and 3-chloro-2-fluoro-5-(trifluoromethyl)pyridine (Aldrich) in a manner similar to that described for EXAMPLE 94, Step 3.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-f4114aff7115488aabe5d9c7fbdc963f
来源数据集: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US09346798B2
来源说明: uspto-grants-2016_05

反应SMILES

[CH3:1][O:2][C:3]1[CH:29]=[CH:28][C:6]([CH2:7][N:8]([C:22]2[CH:27]=[CH:26][N:25]=[CH:24][N:23]=2)[S:9]([C:12]2[CH:13]=[CH:14][C:15]3[NH:20][CH2:19][CH2:18][O:17][C:16]=3[CH:21]=2)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[Cl:30][C:31]1[C:32](F)=[N:33][CH:34]=[C:35]([C:37]([F:40])([F:39])[F:38])[CH:36]=1>>[Cl:30][C:31]1[C:32]([N:20]2[CH2:19][CH2:18][O:17][C:16]3[CH:21]=[C:12]([S:9]([N:8]([CH2:7][C:6]4[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:29][CH:28]=4)[C:22]4[CH:27]=[CH:26][N:25]=[CH:24][N:23]=4)(=[O:11])=[O:10])[CH:13]=[CH:14][C:15]2=3)=[N:33][CH:34]=[C:35]([C:37]([F:39])([F:38])[F:40])[CH:36]=1