Water → HCID 89761995, compound

Participants

Reaction Steps

In a 10-mL round bottom flask under N2 was dissolved cesium carbonate (807 mg, 2.48 mmol) and 3-hydroxy-4-((2-methoxy-4-(trifluoromethyl)phenyl)amino)-N-(4-methoxybenzyl)-N-(thiazol-2-yl)benzenesulfonamide (350 mg, 0.619 mmol) in 4 mL of DMF followed by a slow addition of chloroacetyl chloride (0.099 mL, 1.24 mmol) at rt. After 1 h the reaction mixture was neutralized with H2O and ice and the product 4-(2-methoxy-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-3-oxo-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide was collected as a solid and dried under reduced pressure and used directly in the next step.

Provenance & Evidence