HCID 18475684, compound → 6-Fluoroquinoline-4-carboxylic acid
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7](C(O)=O)[CH:6]=[C:5]2[C:15]([OH:17])=[O:16]>O>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2[C:15]([OH:17])=[O:16]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 200 °C
Procedure
6-Fluoroquinoline-2,4-dicarboxylic acid (0.103 g, 0.437 mmol) was transferred in a pressure tube, 6 mL water was added. The closed tube was heated to 200° C. for 4 h. After slow cooling of the tube, the resulting precipitate was filtered and washed with water to yield white crystals
Workup
- temperatureAfter slow cooling of the tube
- filtrationthe resulting precipitate was filtered
- washwashed with water
- customto yield white crystals
Sources & evidence
- ORD record
- ord-2b5f23041ee34ff8aa099d0a96c4a1bd
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09346814B2
Reaction notes
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