1,4-Dioxane → HCID 89704970, compound

Participants

Reaction Steps

To a solution containing this acid 5-phenylquinoline-4-carboxylic acid (0.04 g, 0.160 mmol) and HOBT (Hydroxybenzotriazole) (0.027 g, 0.177 mmol) in 1,4-dioxane (5 mL) was added a solution of EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide HCl) (0.034 g, 0.177 mmol) in CH2Cl2 (5 mL). The mixture was stirred for 10 min at room temperature. To the resulting solution was added the appropriate amine (S)-1-(2-aminoacetyl)pyrrolidine-2-carbonitrile 4-methylbenzenesulfonate (0.063 g, 0.193 mmol) and DIPEA (0.059 ml, 0.337 mmol) in CH2Cl2 (4 mL), with stirring.

Provenance & Evidence