HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 89705260, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 75539583 | HCID 75539583 | — |
| Reactant | HCID 81456049 | HCID 81456049 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 89705260 | HCID 89705260 | — |
Reaction Steps
(2R)-2-((3aS,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)pyrrolidine hydrochloride (0.190 g, 0.665 mmol) was added to a mixture of 2-(quinoline-4-carboxamido)acetic acid (0.153 g, 0.665 mmol), HATU (0.253 g, 0.665 mmol) and DIPEA (0.360 ml, 2.062 mmol) in dichloromethane (5 mL). The mixture was stirred for 3 h and washed with 0.5N citric acid, saturated sodium bicarbonate and brine, followed by filtration and evaporation. Purification was done using column chromatography DCM-MeOH 0-6% MeOH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09346814B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-f9b4a53875f44c9298d3e5c9e1426792 |
| Source note | uspto-grants-2016_05 |