反应详情

To a solution of cis/trans-4-isobutyl-cyclohexanecarboxylic acid (7:3) (1.0 g, 5.4 mmol) in methanol (54 ml) was added a catalytic amount of sulfuric acid (2 drops). The reaction mixture was heated at reflux for 16 h. The solvent was evaporated. The residue was diluted with tert-butyl methyl ether (100 ml) and washed with aqueous saturated sodium hydrogen carbonate solution (50 ml). The organic layer was dried over anhydrous sodium sulfate and concentrated to dryness to give the title compound ((7:3) cis/trans mixture) as a light yellow oil. MS m/e: 198 (M+)

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 16 h
3. customThe solvent was evaporated
4. additionThe residue was diluted with tert-butyl methyl ether (100 ml)
5. washwashed with aqueous saturated sodium hydrogen carbonate solution (50 ml)
6. dry with materialThe organic layer was dried over anhydrous sodium sulfate
7. concentrationconcentrated to dryness