HCID 67979496, compound → HCID 178430785, compound

HRID 528715Notes

Reaction equation

HRID 528715 reaction equation
C(O[C:4]([CH:6]1[C:12](=O)[CH2:11][CH2:10][N:9]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:8][CH:7]1[CH3:21])=[O:5])C.[NH2:22][C:23]1[CH:27]=[CH:26][NH:25][N:24]=1>C(O)(=O)C>[C:17]([O:16][C:14]([N:9]1[CH2:8][CH:7]([CH3:21])[C:6]2=[C:4]([OH:5])[N:24]3[C:23]([N:22]=[C:12]2[CH2:11][CH2:10]1)=[CH:27][CH:26]=[N:25]3)=[O:15])([CH3:18])([CH3:19])[CH3:20]

Participants

4

Reactant 2

HCID 67979496HCID 67979496, compoundHCID 178418806HCID 178418806, compound

Product 1

HCID 178430785HCID 178430785, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 1.95 g (6.23 mmol) 3-methyl-5-oxo-azepane-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester in 10 mL acetic acid was added 0.52 g (6.23 mmol) 3-aminopyrazole and the reaction mixture was heated at 80° C. for 3 hours. After the reaction was cooled at room temperature, the solvent was evaporated and the product purified by column chromatography (silica, DCM/MeOH 95:5).

Workup

  1. temperatureAfter the reaction was cooled at room temperature
  2. customthe solvent was evaporated
  3. customthe product purified by column chromatography (silica, DCM/MeOH 95:5)

Sources & evidence

ORD record
ord-608f7faa0cef4f409c0307bdaececb1b
Source dataset
uspto-grants-2016_05
Patent number
US09346816B2

Reaction notes

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