1-Benzyl 4-ethyl 5-oxoazepane-1,4-dicarboxylate → HCID 178525106, compound

HRID 528722Notes

Reaction equation

HRID 528722 reaction equation
C(O[C:4]([CH:6]1[C:12](=O)[CH2:11][CH2:10][N:9]([C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])[CH2:8][CH2:7]1)=[O:5])C.[NH2:24][C:25]1[CH:29]=[CH:28][NH:27][N:26]=1>C(O)(=O)C>[CH2:17]([O:16][C:14]([N:9]1[CH2:8][CH2:7][C:6]2=[C:4]([OH:5])[N:26]3[C:25]([N:24]=[C:12]2[CH2:11][CH2:10]1)=[CH:29][CH:28]=[N:27]3)=[O:15])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 146001211-Benzyl 4-ethyl 5-oxoazepane-1,4-dicarboxylateHCID 178418806HCID 178418806, compound

Product 1

HCID 178525106HCID 178525106, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

To 5.87 g (18.38 mmol) 5-oxo-azepane-1,4-dicarboxylic acid 1-benzyl ester 4-ethyl ester in 3 mL acetic acid was added 1.53 g (18.38 mmol) 3-aminopyrazole and the reaction mixture was heated at 80° C. for 15 minutes. The resulting solid was collected by filtration and washed with TBME (3×10 mL) to give the desired product.

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with TBME (3×10 mL)

Sources & evidence

ORD record
ord-635c42cf12ea4dae97fda99dedbd6d5a
Source dataset
uspto-grants-2016_05
Patent number
US09346816B2

Reaction notes

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