Acetamide → 3-(4-Methyl-oxazol-2-yl)-azetidine-1-carboxylic acid benzyl ester

Participants

Reaction Conditions

Reaction Steps

To 130 mg (0.45 mmol) azetidine-1,3-dicarboxylic acid 1-benzyl ester 3-(2-oxo-propyl)ester in 4 mL xylene were added 132 mg (2.25 mmol) acetamide, 39 μL (0.31 mmol) boron trifluoride etherate and the mixture was heated at 130° C. for 24 hours. After cooling to room temperature and evaporation of the solvent the product was purified by chromatography (silica, hexane-EtOAc 6:4).

Provenance & Evidence