反应详情

温度

30 °C

To 40 mg (0.15 mmol) 3-(4-methyl-oxazol-2-yl)-azetidine-1-carboxylic acid benzyl ester in 2 mL ethanol was added 4 mg (20% w/w on carbon) palladium hydroxide, the reaction was purged 3 times with nitrogen then 3 times with hydrogen and was stirred at 30° C. under a balloon of hydrogen for 18 hours. The mixture was purged twice with nitrogen, then the solution was filtered through a pad of celite. The solvent was evaporated to give the desired product, which was used in the next step without further purification.

1. customthe reaction was purged 3 times with nitrogen
2. customThe mixture was purged twice with nitrogen
3. filtrationthe solution was filtered through a pad of celite
4. customThe solvent was evaporated