10-Chloro-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester → 10-(3-Pyrazol-1-ylmethyl-azetidin-1-yl)-6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene
Reaction equation
C(OC([N:8]1[CH2:22][CH2:21][C:12]2=[C:13](Cl)[N:14]3[C:18]([N:19]=[C:11]2[CH2:10][CH2:9]1)=[CH:17][CH:16]=[N:15]3)=O)(C)(C)C.[NH:23]1[CH2:26][CH:25]([CH2:27][N:28]2[CH:32]=[CH:31][CH:30]=[N:29]2)[CH2:24]1>>[N:28]1([CH2:27][CH:25]2[CH2:26][N:23]([C:13]3[N:14]4[C:18]([N:19]=[C:11]5[CH2:10][CH2:9][NH:8][CH2:22][CH2:21][C:12]=35)=[CH:17][CH:16]=[N:15]4)[CH2:24]2)[CH:32]=[CH:31][CH:30]=[N:29]1Participants
3
Procedure
The product was prepared using 10-chloro-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester in route 1 (step e and f), in step e (route 1) 1-azetidin-3-ylmethyl-1H-pyrazole was used as the amine.
Workup
- customThe product was prepared
Sources & evidence
- ORD record
- ord-3e430ab219874a8f9929a488e3ca6f9e
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09346816B2
Reaction notes
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