10-Chloro-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester → HCID 67979379, compound

HRID 528763Notes

Reaction equation

HRID 528763 reaction equation
C(OC([N:8]1[CH2:22][CH2:21][C:12]2=[C:13](Cl)[N:14]3[C:18]([N:19]=[C:11]2[CH2:10][CH2:9]1)=[CH:17][CH:16]=[N:15]3)=O)(C)(C)C.FC(F)(F)C(O)=O.[NH:30]1[CH2:33][CH:32]([C:34]([C:36]2[CH:41]=[CH:40][C:39]([O:42][CH3:43])=[CH:38][CH:37]=2)=[O:35])[CH2:31]1>>[CH3:43][O:42][C:39]1[CH:40]=[CH:41][C:36]([C:34]([CH:32]2[CH2:31][N:30]([C:13]3[N:14]4[C:18]([N:19]=[C:11]5[CH2:10][CH2:9][NH:8][CH2:22][CH2:21][C:12]=35)=[CH:17][CH:16]=[N:15]4)[CH2:33]2)=[O:35])=[CH:37][CH:38]=1

Participants

3

Reactant 2

HCID 4692812210-Chloro-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl esterHCID 67458791HCID 67458791, compound

Product 1

HCID 67979379HCID 67979379, compound

Procedure

The product was prepared using 10-chloro-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester in route 1 (step e and f), in step e (route 1) azetidin-3-yl-(4-methoxy-phenyl)-methanone trifluoroacetate was used as the amine.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-350f1264c3764e2db91e44c8e728452d
Source dataset
uspto-grants-2016_05
Patent number
US09346816B2

Reaction notes

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