2-Phenylazetidine → 10-(2-Phenyl-azetidin-1-yl)-6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene
Reaction equation
C(OC([N:8]1[CH2:22][CH2:21][C:12]2=[C:13](Cl)[N:14]3[C:18]([N:19]=[C:11]2[CH2:10][CH2:9]1)=[CH:17][CH:16]=[N:15]3)=O)(C)(C)C.[C:23]1([CH:29]2[CH2:32][CH2:31][NH:30]2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:23]1([CH:29]2[CH2:32][CH2:31][N:30]2[C:13]2[N:14]3[C:18]([N:19]=[C:11]4[CH2:10][CH2:9][NH:8][CH2:22][CH2:21][C:12]=24)=[CH:17][CH:16]=[N:15]3)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1Participants
3
Procedure
The product was prepared using 10-chloro-5,6,8,9-tetrahydro-1,4,7,10a-tetraaza-cyclohepta[f]indene-7-carboxylic acid tert-butyl ester in route 1 (step e and f), in step e (route 1) 2-phenyl-azetidine was used as the amine.
Workup
- customThe product was prepared
Sources & evidence
- ORD record
- ord-04eb4130ed544c308f8c2f237ce8c570
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09346816B2
Reaction notes
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