HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Chloropropyl)-pyrrolidine → 7-(3-(Pyrrolidin-1-yl)propoxy)naphthalene-2-sulfonic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Chloropropyl)-pyrrolidine | HCID 11321028 | — |
| Reactant | Sodium 7-oxidonaphthalene-2-sulfonate | HCID 86718866 | — |
| Product | 7-(3-(Pyrrolidin-1-yl)propoxy)naphthalene-2-sulfonic acid | HCID 86718873 | 55% |
Reaction Steps
Following a procedure analogous to that for the synthesis of Intermediate 26B, sodium 7-oxidonaphthalene-2-sulfonate (Pfaltz and Bauer, 200 mg, 0.75 mmol) and 1-(3-chloropropyl)pyrrolidine (110 mg, 0.75 mmol) were converted to the title compound (138 mg, 55%). MS(ESI+) m/z 336.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09346795B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-540d707212b54688b1158e05a96daf45 |
| Source note | uspto-grants-2016_05 |