1-ethyl-2,3-dihydro-1H-indole-5-sulfonamide → 1-Ethylindoline-6-sulfonamide

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Reaction Steps

Following a procedure analogous to that for the synthesis of Intermediate 53, 1-acetylindoline-6-sulfonamide (Intermediate 60, 200 mg, 0.83 mmol) was converted to the title compound (50 mg, 27%) after purification using preparative HPLC. 1H NMR (CDCl3) δ 7.37 (d, J=7.5 Hz, 1H), 7.21 (d, J=9.7 Hz, 2H), 3.59 (t, J=8.1 Hz, 2H), 3.28 (q, J=8.1 Hz, 2H), 3.10 (t, J=8.1 Hz, 2H), 1.26-1.22 (m, 3H); MS(ESI+) m/z 227.1 (M+H)+.

Provenance & Evidence